Fig. 8

KPCML1 mice exhibit a similar transcriptomic profile to that of cachectic PDAC patients. A Volcano plots of DEGs from RNA-seq results from muscles of cachectic PDAC patients in comparison to muscles from KPCML1 mice (with and without metastasis) and KPP, C-26, and LLC mouse models of cancer cachexia. B GO graphs generated from the downregulated genes of subgroups shown in (A). Solid Arrows indicate pathways that are similar between muscles from cachectic pancreatic cancer patients and KPP and KPCML1 mouse models, in contrast to those pathways indicated by empty arrows that differ between muscles patients and C-26 and LLC mouse models