Table 2 Univariate and multivariate analyses of prognostic factors for overall survival following radical gastrectomy of stage II/III gastric cancer in the training cohort (n = 749)

Gender

0.287

 Male

501

54.0

 Female

248

47.0

Age (years)

0.177

 ≥ 65

147

45.0

 < 65

602

56.0

Body mass index (kg/m²)

< 0.001

0.003

 ≥ 25.0

108

77.0

Reference

 18.5–24.9

566

53.0

1.296 (0.926–1.814)

 < 18.5

75

29.0

2.086 (1.356–3.208)

ASA score

0.993

 ≥ 3

58

56.0

 < 3

691

53.0

Comorbidities

0.326

 Yes

217

67.0

 No

532

49.0

Hemoglobin (g/L)

0.524

 ≥ 100

581

54.0

 < 100

168

50.0

Albumin level (g/L)

0.745

 ≥ 35

608

56.0

 < 35

139

47.0

Lymphocyte count (×10 ⁹/L)

0.744

 ≥ 1.5

507

56.0

 < 1.5

242

52.0

Operation procedure

0.152

 Open

561

50.0

 Laparoscopy

188

68.0

Operation time (min)

0.080

 ≥ 240

157

35.0

 < 240

568

56.0

Intra-operative blood loss (mL)

0.003

0.128

 ≥ 300

170

34.0

 < 300

579

63.0

Type of resection

 < 0.001

< 0.001

 Sub-total gastrectomy

524

82.0

Reference

 Total gastrectomy

225

23.0

1.921 (1.545–2.389)

pTNM stage ^†

< 0.001

< 0.001

 II

218

NA*

Reference

 III

531

32.0

2.970 (2.215–3.982)

Peri-operative blood transfusion

0.036

0.945

 Yes

156

37.0

 No

593

56.0

Post-operative complication ^‡

0.314

 Yes

73

39.0

 No

676

56.0

Peri-operative adjuvant chemotherapy

0.001

 0.001

 1 cycles

133

37.0

Reference

 2 cycles

141

35.0

1.103 (0.733–1.401)

 3 cycles

148

45.0

0.995 (0.722–1.373)

 4 cycles

213

91.0

0.549 (0.398–0.758)

 5 cycles

114

72.0

0.609 (0.422–0.880)