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Fig. 5 | BMC Cancer

Fig. 5

From: Knockdown of ribosome RNA processing protein 15 suppresses migration of hepatocellular carcinoma through inhibiting PATZ1-associated LAMC2/FAK pathway

Fig. 5

Knockdown PATZ1 suppressed LAMC2 and LAMB3 transcription in HCC cells. (A) Transcriptional binding site of PATZ1. (B) Correlation of PATZ1 mRNA level with RRP15, LAMC2 and LAMB3 mRNA levels. (C) Protein and mRNA levels of PATZ1 in RRP15 knockdown cells. (D) The knockdown efficiency of PATZ1 in HCC cells. (E-F) Expression levels of the indicated mRNAs in RRP15-overexpressing MHCC-97 H and LM3 cells with or without PATZ1 knockdown. (G) Migration and invasion of RRP15-overexpressing MHCC-97 H and LM3 cells with or without PATZ1 knockdown in the transwell assay. Scale bars = 100 μm. (H) Schematic diagram showing that knockdown of RRP15 inhibits the growth and metastasis of HCC cells via inactivation of the LAMC2 /FAK signaling. Data are presented as means ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001. PATZ1: POZ/BTB and AT hook containing zinc finger 1; LAMC2: laminin subunit gamma 2; LAMB3: laminin subunit beta 3; HCC: hepatocellular carcinoma

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BMC Cancer

ISSN: 1471-2407

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