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Fig. 4 | BMC Cancer

Fig. 4

From: Knockdown of ribosome RNA processing protein 15 suppresses migration of hepatocellular carcinoma through inhibiting PATZ1-associated LAMC2/FAK pathway

Fig. 4

RRP15 enhanced migration of HCC cells through the LAMC2/ITGB4/FAK pathway. (A) The knockdown efficiency of LAMC2 in HCC cells. (B) The overexpression of RRP15 in HCC cells. (C) Expression levels of the indicated proteins in RRP15-overexpressing MHCC-97 H and LM3 cells with or without LAMC2 knockdown. (D-E) Migration and invasion of RRP15-overexpressing MHCC-97 H and LM3 cells with or without LAMC2 knockdown in the transwell assay. Scale bars = 100 μm. Data are presented as mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001. RRP15: ribosomal RNA processing protein 15; LAMC2: laminin subunit gamma 2; ITGB4: integrin subunit beta 4; FAK: focal adhesion kinase; HCC: hepatocellular carcinoma

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BMC Cancer

ISSN: 1471-2407

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