Skip to main content
Fig. 3 | BMC Cancer

Fig. 3

From: Knockdown of ribosome RNA processing protein 15 suppresses migration of hepatocellular carcinoma through inhibiting PATZ1-associated LAMC2/FAK pathway

Fig. 3

RRP15 knockdown inactivated the LAMC2/ITGB4/FAK pathway in HCC cells. (A) The volcano plot of differentially expressed genes (DEGs). The blue dots represent downregulated genes, the grey dots are non-differentially expressed genes and the red dots are upregulated genes. (B) KEGG pathway analysis showing the significantly associated signaling pathways in the RRP15-knockdown MHCC-97 H cells. (C) Heatmap of DEGs. Up- and down-regulated genes are shown in red and blue respectively. (D-E) Effect of RRP15 knockdown on the expression of LAMC2, LAMB3 and LAMA3 mRNAs. (F) Effect of RRP15 knockdown on the expression of LAMC2 and LAMB3 proteins. (G) Immunoblots showing ITGB4, pFAK, pERK, p-p65, FAK, ERK and p65 levels in RRP15-knockdown and control cells. Data are presented as mean ± SEM. *p < 0.05, **p < 0.01. RRP15: ribosomal RNA processing protein 15; LAMC2: laminin subunit gamma 2; ITGB4: integrin subunit beta 4; FAK: focal adhesion kinase; HCC: hepatocellular carcinoma; LAMB3: laminin subunit beta 3; ERK: mitogen-activated protein kinase 1

Back to article page

BMC Cancer

ISSN: 1471-2407

Contact us