Skip to main content
Fig. 2 | BMC Cancer

Fig. 2

From: Knockdown of ribosome RNA processing protein 15 suppresses migration of hepatocellular carcinoma through inhibiting PATZ1-associated LAMC2/FAK pathway

Fig. 2

RRP15 knockdown attenuated the migration and invasion of HCC. (A) The knockdown efficiency of RRP15 in HCC cells. (B) Downregulation of RRP15 inhibited migration of HCC cell in the wound healing assay. Scale bars = 100 μm. (C-D) Migration and invasion of MHCC-97 H or LM3 cells transfected with shNT or shRRP15 in the transwell assay. Scale bars = 100 μm. (E) Downregulation of RRP15 inhibited adhesion of HCC cells. Scale bars = 100 μm. (F) Expression levels of EMT-related proteins in MHCC-97 H or LM3 cells transfected with shNT or shRRP15. (G) Representative images of lung metastases observed under a stereoscope. Scale bars = 1 cm. (H) Number of metastatic nodules in the lung tissues in the indicated groups (n = 8 per group). (I) Representative images of H&E-stained lung tissue sections in shNT/shRRP15 mice. Scale bars = 100 μm. Data are presented as mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001. RRP15: ribosomal RNA processing protein 15; HCC: hepatocellular carcinoma. H&E: hematoxylin and eosin

Back to article page

BMC Cancer

ISSN: 1471-2407

Contact us