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Table 4 The logistic regression analysis and consequent odds ratios for subjects with MM and KC and/or PM lesions compared to subjects with MM only

From: Spectrum of malignant and premalignant skin lesions in 505 adult subjects at risk of skin cancers

 

Univariate OR

P-value

95% CI

Multivariate OR

P-value

95% CI

Age years

1.169

 < 0.001

1.099–1.242

1.388

 < 0.001

1.163–1.656

Sex

 Male

1 (ref)

0.441

0.337–1.606

1 (ref)

  

 Female

0.736

5.653

0.144

0.554–57.715

Immunosuppression

 No

1 (ref)

0.265

0.544–9.177

1 (ref)

0.303

0.161–354.972

 Yes

2.234

7.570

Occupation type

 mainly indoor

1 (ref)

0.015

1.231–6.934

1 (ref)

0.350

0.353–18.937

 mainly outdoor/mix

2.922

2.586

Lifetime sunburns

 rarely

1 (ref)

  

1 (ref)

  

 occasionally

0.207

0.005

0.069–0.619

0.038

0.007

0.004–0.401

 often

0.500

0.249

0.154–1.624

4.068

0.311

0.269–61.560

Number of moles

 0–20

1 (ref)

  

1 (ref)

  

 21–50

0.271

0.016

0.093–0.785

0.111

0.071

0.010–1.204

 51–100

0.290

0.037

0.091–0.927

1.563

0.723

0.132–18.526

 over 100 mol

0.243

0.028

0.069–0.856

2.967

0.617

0.042–210.301

ASA use

 no

1 (ref)

  

1 (ref)

  

 occasional

0.697

0.639

0.154–3.153

0.010

0.031

0.000–0.666

 regular

3.152

0.023

1.170–8.489

4.610

0.214

0.414–51.354

NSAID use

 no

1 (ref)

  

1 (ref)

  

 occasional

0.382

0.028

0.162–0.900

0.572

0.591

0.075–4.372

 regular

0.441

0.269

0.104–1.881

0.062

0.135

0.002–2.374

Platelet-to-lymphocyte-ratio

1.004

0.371

0.996–1.012

1.028

0.023

1.004–1.053

Family history of MM

 No

1 (ref)

  

1 (ref)

  

 One MM case in family

1.696

0.475

0.398–7.229

50.273

0.078

0.645–3916.795

 2 or more MM cases

0.283

0.135

0.054–1.481

0.062

0.098

0.002–1.670

AMS

 no

1 (ref)

  

1 (ref)

  

 yes

0.343

0.066

0.110–1.073

0.060

0.119

0.002-2.056

  1. The multivariate ORs adjusted for all covariates presented in the table. The statistically significant values are in bold. Abbreviations:CI, confidence interval; MM, melanoma; KC, keratinocyte carcinoma; PM premalignant; NSAID, non-steroidal anti-inflammatory agent; AMS atypic mole syndrome; ASA acetylsalicylic acid