Impact of preoperative white blood cell count on outcomes in different stage colorectal cancer patients undergoing surgical resection: a single-institution retrospective cohort study

Wang, Bei; Ling, Dandan; Li, Lihong; Zhang, Jun; Xu, Jianghui

doi:10.1186/s12885-024-11983-7

Table 1 Patients characteristics of the high preoperative WBC count group and the low preoperative WBC count group before and after IPTW. WBC, white blood cell; IPTW, inverse probability of treatment weighting

From: Impact of preoperative white blood cell count on outcomes in different stage colorectal cancer patients undergoing surgical resection: a single-institution retrospective cohort study

Variables	Entire study population				Weighted covariates
Variables	Low pre-WBC count n = 6236	High pre-WBC count n = 1885	P value	Standardized difference (%)	Low pre-WBC count n = 6235.3	High pre-WBC count n = 1889.2	P value	Standardized difference (%)
Gender			< 0.001	0.144			0.808	0.007
Female	2642[42.4]	667[35.4]			2541.4[40.8]	776.2[41.1]
Male	3594[57.6]	1218[64.6]			3693.9[59.2]	1113.0[58.9]
Treat year			0.916	0.003			0.721	0.010
2008–2012	3902[63]	1182[63]			3906.0[62.6]	1192.3[63.1]
2013–2014	2334 [37]	703 [37]			2329.3[37.4]	696.9[36.9]
Age[years]			0.446	0.050			0.996	0.012
=<44	799[12.8]	269[14.3]			822.1[13.2]	252.2[13.3]
45–54	1247[20.0]	386[20.5]			1253.2[20.1]	379.7[20.1]
55–64	2263[36.3]	652[34.6]			2235.4[35.8]	670.4[35.5]
65–74	1342[21.5]	404[21.4]			1340.6[21.5]	404.9[21.4]
>=75	585[9.4]	174[9.2]			584.1[9.4]	182.0[9.6]
Stage			< 0.001	0.218			0.992	0.014
I	1185[19.0]	259[13.7]			1109.6[17.8]	339.6[18.0]
II	1665[26.7]	578[30.7]			1722.1[27.6]	519.7[27.5]
III	2445[39.2]	707[37.5]			2419.4[38.8]	729.7[38.6]
IV	756[12.1]	313[16.6]			820.4[13.2]	246.6[13.1]
Unknown	185[3.0]	28[1.5]			163.9[2.6]	53.5[2.8]
Tumor location			< 0.001	0.120			0.978	0.012
Rectal	3381[54.2]	909[48.2]			3295.9[52.9]	1008.0[53.4]
Left colon	1283[20.6]	433[23.0]			1316.1[21.1]	392.5[20.8]
Right colon	1560[25.0]	539[28.6]			1611.0[25.8]	484.5[25.6]
Total colon	12[0.2]	4[0.2]			12.4[0.2]	4.2[0.2]
Tumor pathological type			< 0.001	0.109			0.987	0.004
Adenocarcinoma	5460[87.6]	1579[83.8]			5403.7[86.7]	1635.3[86.6]
Mucoid adenocarcinoma	690[11.1]	270[14.3]			737.6[11.8]	224.6[11.9]
Signet cell cancer	86[1.4]	36[1.9]			94[1.5]	29.3[1.6]
Tumor differentiation			< 0.001	0.130			0.959	0.016
Poor	1229[19.7]	452[24.0]			1291.2[20.7]	392.1[20.8]
Moderate	4233[67.9]	1254[66.5]			4211.5[67.5]	1267.7[67.1]
Well	143[2.3]	29[1.5]			132.5[2.1]	43.8[2.3]
Unknown	631[10.1]	150[8.0]			600.1[9.6]	185.6[9.8]
Vascular tumor thrombus			0.118	0.042			0.872	0.004
Yes	1402[22.5]	457[24.2]			1426.1[22.9]	428.7[22.7]
No	4834[77.5]	1428[75.8]			4809.2[77.1]	1460.5[77.3]
Perineural invasion			0.776	0.008			0.898	0.003
Yes	1187[19.0]	365[19.4]			1192.1[19.1]	358.7[19.0]
No	5049[81.0]	1520[80.6]			5043.2[80.9]	1530.5[81.0]
Surgical margin positivity			0.011	0.065
Yes	90[1.4]	44[2.3]			102.9[1.7]	30.9[1.6]	0.964	0.001
No	6146[98.6]	1841[97.7]			6132.4[98.3]	1858.3[98.4]
Surgical procedure			0.794	0.008			0.882	0.004
Open	5737[92.0]	1730[91.8]			5733.1[91.9]	1735[91.8]
Video-assisted	499[8.0]	155[8.2]			502.2[8.1]	154.2[8.2]
Preoperative chemotherapy			< 0.001	0.128			0.700	0.012
Yes	566[9.1]	108[5.7]			518.5[8.3]	163.4[8.6]
No	5670[90.9]	1777[94.3]			5716.8[91.7]	1725.8[91.4]
Cancer node			0.331	0.026			0.977	0.001
>=1	946[15.2]	304[16.1]			959[15.4]	291.4[15.4]
0	5290[84.8]	1579[83.9]			5276.3[84.6]	1597.8[84.6]

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