Fig. 5

Schematic diagram of the pathogenic mechanism. (A) In the pantothenate and CoA biosynthesis pathways, the boxes represent protein molecules, the circles represent metabolic molecules, and the blue color represents decreases in the levels of substances. (B) Relationships among the gut microbiota, intestinal metabolites, number of peripheral blood cells and ESCC incidence are depicted; blue indicates a decrease, and red indicates an increase