Using a combination of superb microvascular imaging and other auxiliary ultrasound techniques to increase the accuracy of gray-scale ultrasound for breast masses

Table 4 Sensitivities, specificities, predictive values, and likelihood ratios of breast ultrasound BIRADS, vascular ratios and scores of SMI, color Doppler ultrasound and power ultrasound; and combination models for all breast lesions

	AUC	SE (AUC)	Cutoff points	SE (%)	SP (%)	PPV (%)	NPV (%)	PLR (%)	NLR (%)	Accuracy (%)
US BIRADS	---	---	---	100	46.10	29.00	100	1.86	0.00	55.80
SMI VS	0.696	0.047	28.5	64.50	65.50	28.60	89.20	1.82	0.55	64.53
SMI VR	0.660	0.047	0.2303	67.70	60.28	27.27	89.47	1.71	0.54	61.63
DUS VS	0.739	0.050	39.3	70.97	61.87	29.33	90.53	1.86	0.47	63.53
DUS VR	0.676	0.047	0.2074	64.52	63.12	27.78	89.02	1.75	0.56	63.37
PUS VS	0.726	0.050	52.0	70.00	60.28	27.27	90.43	1.76	0.50	61.99
PUS VR	0.675	0.048	0.269	64.52	60.28	26.32	88.54	1.62	0.59	61.05
Strain ratio	0.805	0.059	3.09	90.00	62.14	33.75	96.67	2.38	0.16	67.06
US + SMI	-	-	-	100	61.2	43.5	100	2.58	0.00	70.11
US + DUS	-	-	-	100	63.9	46.3	100	2.77	0.00	72.50
Strain ratio + US	-	-	-	90.0	79.3	48.2	97.4	4.34	0.13	81.18
Strain ratio + SMI	-	-	-	94.4	74.4	45.9	98.3	3.68	0.07	78.12
US + DUS + SMI	-	-	-	46.3	100	100	63.9	∞	0.54	72.50
US + STE + DUS	-	-	-	65.8	100	100	59.4	∞	0.34	77.19
US + STE + SMI	-	-	-	100	74.4	63.0	100	3.90	0.00	82.14

Those with no vessels got a zero value. In the combination models: for DUS and SMI, the vascular score; for STE, the strain ratio; and for US, BIRADS is considered. The combinations of modalities consist of considering a positive or negative result when all modalities were positive, or all were negative, respectively
AUC Area under the curve, DUS Color Doppler ultrasound, NLR Negative likelihood ratio, NPV Negative predictive value, PLR Positive likelihood ratio, PPV Positive predictive value, PUS Power ultrasound, SE Sensitivity, SMI Superb microvascular imaging, SP Specificity, STE Strain elastography, VR Vascular ratio, VS Vascular score

ISSN: 1471-2407