Table 2 Univariate and multivariate analyses for OS in patients of ICC with distant metastasis

Gender

Female

Ref

Ref

Male

1.393

1.131–1.717

0.002

1.18

0.947–1.472

0.139

Age

<65

Ref

Ref

65

1.300

1.059–1.596

0.012

1.497

1.177–1.904

0.001

Race

Black

Ref

Ref

White

0.825

0.498–1.367

0.456

0.895

0.501–1.598

0.707

Others

0.761

0.438–1.323

0.333

0.738

0.399–1.367

0.331

Surgery

No

Ref

Ref

Yes

0.629

0.466–0.847

0.002

0.544

0.391–0.758

< 0.001

Radiotherapy

No

Ref

Ref

Yes

1.289

1.018–1.539

0.04

0.489

0.342–0.713

< 0.001

Chemotherapy

No

Ref

Ref

Yes

0.284

0.225–0.359

< 0.001

0.191

0.146–0.250

< 0.001

T stage

T1

Ref

Ref

T2

1.021

0.767–1.274

0.418

1.130

0.861–1.480

0.373

T3

1.272

1.109–1.653

0.046

1.558

1.112–2.185

0.009

T4

1.486

1.192–1.814

0.012

2.119

1.255–3.577

0.004

LN metastasis

Absent

Ref

Ref

Present

1.318

1.010–1.519

0.028

1.253

0.798–0.964

0.047

Bone Metastasis

Absent

Ref

Ref

Present

1.287

1.479–1.841

0.041

1.440

1.016–2.041

0.040

Liver Metastasis

Absent

Ref

Ref

Present

1.254

0.993–1.583

0.058

1.255

0.899–1.752

0.183

Lung Metastasis

Absent

Ref

Ref

Present

1.533

1.210–1.943

< 0.001

1.247

0.905–1.718

0.177

Grade

I + II

Ref

Ref

III + IV

1.314

1.018–1.671

0.045

1.289

1.033–1.609

0.025

Tumor size

≤ 5 cm

Ref

Ref

>5 cm

1.198

0.927–1.548

0.168

1.138

0.839–1.545

0.406