Fig. 5
From: MZ1, a BRD4 inhibitor, exerted its anti-cancer effects by suppressing SDC1 in glioblastoma
MZ1 inhibited the development of transplanted tumors in nude mice. a The growth of transplanted tumors under the armpits of nude mice in the control group (NC) and the MZ1-treated group. b Tumor volume statistics on the days as shown in the figure for the control group (NC) and the MZ1-treated group. The blue line represented the control group, while the red line represented the MZ1-treated group. c Final tumor mass statistics for the control group and the MZ1-treated group. d Weight statistics for mice in the control group (NC) and the MZ1-treated group on the days as shown in the figure. The blue line represented the control group, while the red line represented the MZ1-treated group. e IHC staining was performed to assess the protein expression of BRD4 and Ki-67 in tumors from the control group (NC) and the MZ1-treated group. The black scale bar represented 50 μm. f HE staining was performed to assess the tissue damage in the lungs, liver, and kidney of mice from the control group (NC) and the MZ1-treated group. The black scale bar represented 50 μm. g Western blot was used to measure the protein expression levels of BRD4 and PCNA in tumors from the control group (NC) and the MZ1-treated group, with GAPDH serving as the internal reference. Data was presented as Mean ± SD. Student’s t-test, *p < 0.05, **p < 0.01; ns, non-significant