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Fig. 5 | BMC Cancer

Fig. 5

From: SIRT7 promotes the proliferation and migration of anaplastic thyroid cancer cells by regulating the desuccinylation of KIF23

Fig. 5

Silencing of SIRT7 reversed cell viability and migration of 8505C and BCPAP cells induced by KIF23. A Overexpression KIF23 in 8505C and BCPAP cells; B CCK-8 assay was performed to assess the cell viability of 8505C and BCPAP cells transfected with si-RNA negative control (si-NC), SIRT7 knockdown plasmid (si-SIRT7) and KIF23 overexpression vector; C Wound healing and transwell migration assays were used to evaluate cell migration of 8505C and BCPAP cells in each group; D The wound healing area and E the number of migrated cells of each group. (**p < 0.01 vs. vector + si-NC group; ##p < 0.01 vs. KIF23 + si-NC group). KIF23, kinesin family member 23; HEK, human embryonic kidney; SIRT, sirtuin; siRNA, small interfering RNA; CCK-8, cell counting kit-8

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BMC Cancer

ISSN: 1471-2407

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