Table 2 Spearman correlation analysis of CAF statuses and tumor tissue levels of selected proteins
From: Dual effect of vitamin D3 on breast cancer-associated fibroblasts
VDR level | CYP24A1 level | CYP27B1 level | OPN level | TGFβ1 level | β-catenin level | |
|---|---|---|---|---|---|---|
CAF activation and protein levels | ||||||
All patients | 0.11 (− 0.35 to 0.14) | − 0.016 (− 0.39 to 0.80) | − 0.25 (− 0.47 to − 0.004)* | 0.098 (− 0.14 to 0.33) | − 0.1479 (− 0.40 to 0.13) | − 0.20 (− 0.44 to 0.61) |
CAF density and protein levels | ||||||
All patients | − 0.66 (− 0.31 to 0.19) | − 0.25 (− 0.46 to − 0.000)* | 0.021 (− 0.23 to 0.27) | 0.29 (0.047 to 0.50)* | 0.013 (− 0.26 to 0.29) | − 0.060 (− 0.32 to 0.21) |
CAF infiltration and protein levels | ||||||
All patients | − 0.17 (− 0.41 to 0.082) | − 0.25 (− 0.46 to − 0.005)* | − 0.12 (− 0.36 to 0.14) | 0.25 (0.009 to 0.46)* | − 0.079 (− 0.34 to 0.20) | − 0.15 (− 0.39 to 0.11) |
Premenopausal | − 0.42 (− 073 to 0.041) | − 0.11 (− 0.54 to 0.36) | − 0.30 (− 0.66 to 0.018) | 0.22 (− 0.25 to 0.60) | 0.00 − 0.52 to 0.60) | − 0.018 (− 0.48 to 0.45) |
Postmenopausal | − 0.048 (− 0.35 to 0.26) | − 0.23 (− 0.49 to 0.068) | − 0.095 (− 0.39 to 0.22) | 0.26 (− 0.03 to 0.52) | 0.052 (− 0.28 to 0.37) | − 0.25 (− 0.53 to 0.077) |
Vitamin D3—deficient | − 0.1281 (− 0.41 to 0.18) | − 0.38 (− 0.60 to − 0.10)** | − 0.060 (− 0.35 to 0.24) | 0.40 (0.13 to 0.61)** | − 0.025 (− 0.35 to 0.30) | − 0.049 (− 0.35 to 0.26) |
Vitamin D3—normal | − 0.31 (− 0.67 to 0.16) | − 0.29 (− 0.69 to 0.23) | − 0.21 (− 0.61 to 0.29) | − 0.054 (− 0.50 to 0.41) | − 0.14 (− 0.62 to 0.41) | − 0.20 (− 0.62 to 0.31) |
Metastases present | − 0.24 (− 0.61 to 0.22) | − 0.031 (− 0.43 to 0.38) | 0.015 (− 0.40 to 0.43) | 0.32 − 0.098 to 0.64) | − 0.25 (− 0.66 to 0.28) | − 0.048 (− 0.48 to 0.40) |
Metastases absent | − 0.19 (− 0.47 to 0.13) | − 0.27 (− 0.53 to 0.039) | − 0.13 (− 0.43 to 0.19) | 0.23 (− 0.077 to 0.50) | − 0.021 (− 0.36 to 0.32) | − 0.17 (− 0.47 to 0.16) |