Table 2 Cox proportional hazards regression to predict recurrence based on Lasso regression

Gender (Male/Female)

1.46

3.57

3.31 [1.52, 7.20]

0.003

Drinking History

1.13

3.16

0.37 [0.18, 0.73]

0.004

Complications

0.66

2.2

0.49 [0.26, 0.92]

0.025

Tumor size (>2.5 cm/≤2.5 cm)

0.51

1.6

1.38 [0.73, 2.61]

0.084

CA19-9 (>54.87/≤54.87)

1.17

2.87

3.51 [1.33, 9.24]

0.011

CA19-9/GGT (>0.15/≤0.15)

0.80

2.11

8.19 [3.37, 19.92]

< 0.001

PLR (>265.81/≤265.81)

0.36

1.11

1.49 [0.77, 2.88]

0.237

GPR (>3.75/≤3.75)

-0.59

-1.46

0.64 [0.29, 1.40]

0.264

AJCC 8th edition TNM stage

0.25

1.94

0.97 [0.46, 2.07]

0.054

IB

0.73

0.49

1.89 [0.09, 10.66]

0.077

IIA

0.77

0.6

3.68 [0.14, 4.71]

0.056

IIB

1.58

1.16

0.97 [0.03, 3.55]

0.087

IIIA

1.78

1.31

0.52 [0.18, 1.56]

0.146

Diferentiation

0.40

1.31

2.08 [0.82, 5.28]

0.067

II

0.13

0.13

1.49 [0.82, 2.69]

0.049

III

1.02

1.01

1.50 [0.66, 3.43]

0.135

Lymph node invasion

2.30

1.42

2.30 [0.91, 5.79]

0.068