Fig. 1

ST14 expression in different datasets from patients with ovarian cancer. (A) Oncomine analysis of the mRNA expression levels of ST14 genes in different cancers. The differences in expression levels of genes between cancer and normal tissues are concluded. The thresholds are indicated in the colored cells. P < 0.05, fold-change > 2 and gene rank = 10% were considered statistically significant. Red cells represent overexpression of the target gene in tumor tissues compared to normal tissues, while blue cells indicate downregulation of the gene. Gene rank is depicted by the color depth in the cells. (B) UALCAN analysis of the mRNA expression levels of ST14 genes in different cancers. (C) GEPIA analysis of the mRNA expression levels of ST14 genes in different cancers. (D) ST14 DNA copy numbers based on chips for ovarian cancer research in TCGA Ovary. *P < 0.05. (E) Levels of ST14 mRNA in ovarian cancer based on research in the GEPIA websites (red for tumor, black for normal). The boxplot analysis showed the expression level by log2 (TPM + 1) on a log-scale. *P < 0.05. (F) Correlation between ST14 and TMEFF1 expression in ovarian cancer based on the GEPIA website. R = 0.32, ***P < 0.001. (G) The expression of ST14 and TMEFF1 in ovarian malignant tumor tissues and normal tissues detected by western blot. (H) Quantification of TMEFF1 normalized to GAPDH. Data are presented as the mean ± SEM (n = 3 per group). *P < 0.05, **P < 0.01, and ***P < 0.001