Table 3 Disease-free survival analysis of the prognostic significance of single cell invasion, nuclear diameter and clinicopathologic characteristics of early oral tongue cancer (n = 311 patients)
Parameter | Univariable Analysis | Multivariable Analysis |
|---|---|---|
HR (95%CI), P value | HR (95%CI), P value | |
Age | ||
≤ 60 years | Reference | Reference |
> 60 years | 1.786 (1.143–2.790), P = 0.011 | 1.948 (1.224–3.101), P = 0.005 |
Gender | ||
Male | Reference | Reference |
Female | 1.081 (0.711–1.642), P = 0.715 | 0.940 (0.604–1.462), P = 0.783 |
Stage | ||
T1N0M0 | Reference | Reference |
T2N0M0 | 0.872 (0.571–1.332), P = 0.526 | 0.831 (0.533–1.296), P = 0.415 |
Differentiation (Grade) | ||
Grade I | Reference | Reference |
Grade II | 1.111 (0.680–1.816), P = 0.673 | 1.236 (0.752–2.033), P = 0.403 |
Grade III | 1.246 (0.717–2.163), P = 0.435 | 1.443 (0.812–2.565), P = 0.211 |
Perineural invasion | ||
None | Reference | Reference |
Yes | 1.462 (0.839–2.549), P = 0.180 | 1.320 (0.741–2.351), P = 0.346 |
Depth of invasion | ||
5 mm or less | Reference | Reference |
More than 5 mm | 1.425 (0.938–2.166), P = 0.097 | 1.394 (0.900-2.159), P = 0.137 |
Single cell invasion | ||
Absent | Reference | Reference |
Present | 1.647 (1.080–2.512), P = 0.021 | 1.666 (1.080–2.571), P = 0.021 |
Nuclear diameter | ||
Small | Reference | Reference |
Large | 1.641 (1.076–2.503), P = 0.021 | 1.645 (1.067–2.538), P = 0.024 |