Table 1 Relationship between single cell invasion, nuclear diameter and clinicopathologic features of early-stage oral tongue cancer
Variable | Single cell invasion | P value | Nuclear diameter | P value | ||
|---|---|---|---|---|---|---|
Absent | Present | Small nuclei | Large nuclei* | |||
Number (%) 168 (54%) | Number (%) 143 (46%) | Number (%) 170 (54.7%) | Number (%) 141 (45.3%) | |||
Age | 0.189 | 0.297 | ||||
≤ 60 years | 64 (49.6%) | 65 (50.4%) | 66 (51.2%) | 63 (48.8%) | ||
> 60 years | 104 (57.1%) | 78 (42.9%) | 104 (57.1%) | 78 (42.9%) | ||
Gender | 0.378 | 0.617 | ||||
Men | 93 (56.4%) | 72 (43.6%) | 88 (53.3%) | 77 (46.7%) | ||
Women | 75 (51.4%) | 71 (48.6%) | 82 (56.2%) | 64 (43.8%) | ||
TNM Stage | 0.483 | 0.225 | ||||
T1N0M0 | 70 (56.5%) | 54 (43.5%) | 73 (58.9%) | 51 (41.1%) | ||
T2N0M0 | 98 (52.4%) | 89 (47.6%) | 97 (51.9%) | 90 (48.1%) | ||
Differentiation (Grade) | 0.020 | 0.158 | ||||
Grade I | 62 (59.0%) | 43 (41.0%) | 56 (53.3%) | 49 (46.7%) | ||
Grade II | 76 (58.0%) | 55 (42.0%) | 79 (60.3%) | 52 (39.7%) | ||
Grade III | 30 (40.0%) | 45 (60.0%) | 35 (46.7%) | 40 (53.3%) | ||
Perineural invasion | 0.058 | 0.020 | ||||
No | 151 (56.1%) | 118 (43.9%) | 154 (57.2%) | 115 (42.8%) | ||
Yes | 17 (40.5%) | 25 (59.5%) | 16 (38.1%) | 26 (61.9%) | ||
Depth of invasion | 0.167 | 0.049 | ||||
Superficial (≤ 5 mm) | 105 (57.4%) | 78 (42.6%) | 109 (59.6%) | 74 (40.4%) | ||
Deep (> 5 mm) | 63 (49.2%) | 65 (50.8%) | 61 (47.7%) | 67 (52.3%) | ||
- | ||||||
Nuclear diameter | < 0.001 | |||||
Small nuclei | 146 (85.9%) | 24 (14.1%) | - | - | ||
Large nuclei | 22 (15.6%) | 119 (84.4%) | - | - | ||
Single cell invasion | - | < 0.001 | ||||
Absent | - | - | 146 (86.9%) | 22 (13.1%) | ||
Present | - | - | 24 (16.8%) | 119 (83.2%) | ||