Table 3 SNPs association with pathomorphological LSCC parameters (bold text highlighting statistically significant results)

Histological grade (G)

G1-2

G3-4

rs2075993

AA

37 (22.3)

2 (5.9)

0.088

Reference

AG

82 (49.4)

20 (58.8)

4.512 (1.002–20.313)

0.050

GG

47 (28.3)

12 (35.3)

4.723 (0.995–22.426)

0.051

G allele non-carriers

37 (22.3)

2 (5.9)

0.031

Reference

G allele carriers

129 (77.7)

32 (94.1)

4.589 (1.050-20.051)

0.043

A allele non-carriers

47 (28.3)

12 (35.3)

0.416

Reference

A allele carriers

119 (71.7)

22 (64.7)

0.724 (0.332–1.580)

0.417

rs3820028

GG

38 (22.9)

2 (5.9)

0.078

Reference

GA

81 (48.8)

20 (58.8)

4.691 (1.043–21.105)

0.044

AA

47 (28.3)

12 (35.3)

4.851 (1.023–23.012)

0.047

A allele non-carriers

38 (22.9)

2 (5.9)

0.032

Reference

A allele carriers

128 (77.1)

32 (94.1)

4.750 (1.088–20.736)

0.038

G allele non-carriers

47 (28.3)

12 (35.3)

0.416

Reference

G allele carriers

119 (71.7)

22 (64.7)

0.724 (0.332–1.580)

0.417

Tumor size (T)

T1-2

T3-4

rs3213180

GG

89 (87.3)

85 (86.7)

0.039

Reference

GC

8 (7.8)

13 (13.3)

1.701 (0.672–4.310)

0.262

CC

5 (4.9)

0 (0.0)

x

C allele non-carriers

89 (87.3)

85 (86.7)

0.913

Reference

C allele carriers

13 (12.7)

13 (13.3)

1.047 (0.459–2.387)

0.913

Lymph node involvement (N)

N0

N1-3

rs3213180

GG

121 (90.3)

53 (80.3)

0.005

Reference

GC

8 (6.0)

13 (19.7)

3.710 (1.452–9.479)

0.006

CC

5 (3.7)

0 (0.0)

x

C allele non-carriers

121 (90.3)

53 (80.3)

0.048

Reference

C allele carriers

13 (9.7)

13 (19.7)

2.283 (0.992–5.256)

0.052

Stage (ST)

ST I-II

ST III-IV

rs3213180

GG

86 (88.7)

88 (85.4)

0.008

Reference

GC

6 (6.2)

15 (14.6)

2.443 (0.906–6.590)

0.078

CC

5 (5.2)

0 (0.0)

x

C allele non-carriers

86 (88.7)

88 (85.4)

0.025

Reference

C allele carriers

11 (11.3)

15 (14.6)

1.333 (0.579–3.065)

0.499