Fig. 1

Oridonin inhibits OS cells viability. A-B 143B and U2OS cells lines were treated with oridonin (0, 5, 10 and 20 μM) for 24 and 48 h. Cell viability was measured by CCK-8 assays. (n = 5, * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001, vs. normal). C-D 143B and U2OS cells treated with oridonin (0, 5, 10 μM). Colony formation was evaluated by colony formation assays. (n = 3, **** p < 0.0001, vs. normal). E-F 143B and U2OS cells lines were treated with oridonin. (0, 5, 10 μM) for 0 h, 12 h and 48 h. Cells migration was evaluated by wound-healing tests (4X). (n = 3, *** p < 0.001, **** p < 0.0001, vs. normal)