Table 4 Univariate logistic regression analysis of the risk factors for radiation pneumonitis

Gender

Male

Female

0.327

1.83 (0.55–6.16)

Age

 < 58

 ≥ 58

0.091

0.35 (0.10–1.18)

Location of the primary site

Upper lobe

Middle and lower lob

0.665

1.30 (0.40–4.25)

TNM stage

IIIA-IIIC

0.580

IVA

0.612

0.65 (0.12–3.47)

IVB

0.770

1.30 (0.23–7.38)

EGFR mutation

EGFR exon 19

EGFR exon 21

0.228

0.48 (0.15–1.58)

No. of lines of aumolertinib

1

2

0.556

0.70 (0.21–2.29)

Time of TKI before TRT (m)

 < 7.7

 ≥ 7.7

0.103

0.26 (0.05–1.32)

Overlap time of TKI and TRT (d)

 < 34

 ≥ 34

0.003

7.20 (1.93–26.81)

Progression before TRT

No

Yes

0.729

0.79 (0.20–3.06)

Total dose (Gy)

 < 52

 ≥ 52

0.052

4.12 (0.99–17.16)

Radiation field

Lung tumor alone

0.010

Lymph node alone

0.149

10.00 (0.44–228.70)

Lung tumor + lymph node

0.003

12.73 (2.43–66.55)

GTV (ml)

 < 21

 ≥ 21

0.001

35.20 (4.08–303.44)

PTV (ml)

 < 116

 ≥ 116

0.001

16.50 (3.16–86.26)