Table 3 Multivariate logistic regression analysis to identify the risk factors for denosumab-induced hypocalcemia
Pretherapeutic factor (reference) | Category or unit | Model 1 | Model 2 | ||||
|---|---|---|---|---|---|---|---|
Odds ratio | 95% CI | P-value | Odds ratio | 95% CI | P-value | ||
Serum calcium level | 1 (mg/dL) | 0.66 | 0.53–0.82 | < 0.001 | |||
Serum calcium level with albumin correction | 1 (mg/dL) | 0.61 | 0.48–0.77 | < 0.001 | |||
Renal function classification (normal) | Mild | 1.33 | 0.86–2.06 | 0.002 | 1.32 | 0.85–2.60 | < 0.001 |
Moderate | 1.00 | 0.59–1.70 | 1.05 | 0.61–1.81 | |||
Severe | 5.38 | 2.22–13.10 | 7.14 | 2.79–18.30 | |||