Table 1 Patient characteristics classified by renal function
Variable | Renal function classification | P-value | Total (n = 524) | |||
|---|---|---|---|---|---|---|
Normal | Mild | Moderate | Severe | |||
(n = 153) | (n = 222) | (n = 117) | (n = 32) | |||
Age (years) | 59.0 ± 10.3 | 70.5 ± 8.3 | 75.6 ± 8.6 | 78.0 ± 10.2 | < 0.001 | 68.7 ± 11.3 |
Sex, male/female (n) | 77/76 | 135/87 | 69/48 | 22/10 | 0.119 | 303/221 |
Body weight (kg) | 60.3 ± 11.9 | 55.9 ± 10.3 | 50.9 ± 11.4 | 49.4 ± 12.2 | < 0.001 | 55.7 ± 11.8 |
(n = 142) | (n = 191) | (n = 99) | (n = 30) | (n = 462) | ||
Serum creatinine (mg/dL) | 0.60 ± 0.12 | 0.76 ± 0.17 | 1.00 ± 0.27 | 2.14 ± 1.23 | < 0.001 | 0.85 ± 0.50 |
Creatinine clearance (mL/min) | 97.8 ± 14.4 | 64.5 ± 8.4 | 41.5 ± 5.6 | 21.2 ± 6.0 | < 0.001 | 66.4 ± 25.6 |
Serum calcium level (mg/dL) | 9.0 ± 0.6 | 9.2 ± 0.8 | 9.4 ± 1.1 | 9.9 + 2.3 | 0.358 | 9.2 ± 1.0 |
Albumin-adjusted serum calcium level (mg/dL) | 9.6 ± 0.6 | 9.6 ± 0.8 | 10.1 ± 1.2 | 10.9 + 2.4 | < 0.001 | 9.8 ± 1.1 |
(n = 149) | (n = 218) | (n = 113) | (n = 32) | (n = 512) | ||
Serum albumin (g/dL) | 3.6 ± 0.7 | 3.6 ± 0.7 | 3.3 ± 0.6 | 3.1 ± 0.7 | < 0.001 | 3.5 ± 0.7 |
(n = 149) | (n = 218) | (n = 113) | (n = 32) | (n = 512) | ||
Serum phosphorus (mg/dL) | 3.3 + 0.8 | 3.4 + 0.7 | 3.3 + 0.6 | 3.8 ± 0.8 | 0.108 | 3.4 ± 0.7 |
(n = 68) | (n = 94) | (n = 59) | (n = 23) | (n = 244) | ||
Cancer type Lung cancer | 61 (40) | 93 (42) | 52 (44) | 13 (41) | 0.084 | 219 (42) |
Breast cancer | 36 (24) | 41 (18) | 13 (11) | 2 (6) | 92 (18) | |
Prostate cancer | 17 (11) | 42 (19) | 21 (18) | 8 (25) | 88 (17) | |
Other | 39 (25) | 46 (21) | 31 (26) | 9 (28) | 125 (24) | |
Prophylactic administration | ||||||
Natural vitamin D ± calcium | 137 (90) | 193 (87) | 92 (79) | 19 (59) | < 0.001 | 441 (84) |
Active vitamin D ± calcium | 7 (5) | 7 (3) | 6 (5) | 7 (22) | 27 (5) | |
Calcium only | 0 (0) | 0 (0) | 0 (0) | 1 (3) | 1 (0.2) | |
None | 9 (6) | 22 (10) | 19 (16) | 5 (16) | 55 (10) | |