Table 7 Treatment-related AEs
Items |  | CRAFITY-low (n = 25) | CRAFITY-intermediate (n = 29) | CRAFITY-high (n = 16) | P Value |
|---|---|---|---|---|---|
Total | Any | 23 (92.00%) | 25 (86.20%) | 14 (87.50%) | 0.790 |
|  | Grade ≥ 3 | 4 (16.00%) | 3 (10.34%) | 2 (12.50%) | 0.824 |
TACE attributed | Â | Â | Â | Â | Â |
Abdominal pain | Any | 20 (80.00%) | 22 (75.86%) | 11 (68.75%) | 0.714 |
|  | Grade ≥ 3 | 0 (00.00%) | 0 (00.00%) | 0 (00.00%) | - |
Fever | Any | 21 (84.00%) | 23 (79.31%) | 13 (81.25%) | 0.906 |
|  | Grade ≥ 3 | 0 (00.00%) | 0 (00.00%) | 0 (00.00%) | - |
Nausea/vomiting | Any | 17 (68.00%) | 21 (72.41%) | 12 (75.00%) | 0.878 |
|  | Grade ≥ 3 | 0 (00.00%) | 0 (00.00%) | 0 (00.00%) | - |
Transaminitis | Any | 22 (88.00%) | 25 (86.21%) | 13 (81.25%) | 0.829 |
|  | Grade ≥ 3 | 0 (00.00%) | 0 (00.00%) | 0 (00.00%) | - |
Systemic therapy attributed | Â | Â | Â | Â | Â |
Fatigue | Any | 6 (24.00%) | 6 (20.69%) | 8 (50.00%) | 0.093 |
|  | Grade ≥ 3 | 0 (00.00%) | 0 (00.00%) | 0 (00.00%) | - |
Secondary Hypertension | Any | 10 (40.00%) | 8 (27.58%) | 5 (31.25%) | 0.618 |
|  | Grade ≥ 3 | 4 (16.00%) | 3 (10.34%) | 2 (12.50%) | 0.824 |
Hand-foot syndrome | Any | 7 (28.00%) | 5 (17.24%) | 5 (31.25%) | 0.495 |
|  | Grade ≥ 3 | 0 (00.00%) | 0 (00.00%) | 0 (00.00%) | - |
Diarrhea/colitis | Any | 2 (8.00%) | 1(3.44%) | 0 (00.00%) | 0.447 |
|  | Grade ≥ 3 | 0 (00.00%) | 0 (00.00%) | 0 (00.00%) | - |
Protein urea | Any | 4 (16.00%) | 4 (13.79%) | 8 (50.00%) | 0.012 |
|  | Grade ≥ 3 | 0 (00.00%) | 0 (00.00%) | 1 (6.25%) | 0.180 |
Hypothyroidism | Any | 1 (4.00%) | 1 (3.45%) | 0 (00.00%) | 0.731 |
|  | Grade ≥ 3 | 0 (00.00%) | 0 (00.00%) | 0 (00.00%) | - |
Constipation | Any | 3 (12.00%) | 5 (6.89%) | 3 (18.75%) | 0.809 |
|  | Grade ≥ 3 | 0 (00.00%) | 0 (00.00%) | 0 (00.00%) | - |
Decreased appetite | Any | 8 (32.00%) | 11 (37.93%) | 9 (75.00%) | 0.289 |
|  | Grade ≥ 3 | 0 (00.00%) | 0 (00.00%) | 0 (00.00%) | - |
Hypothyroidism | Any | 0 (00.00%) | 1 (3.45%) | 0 (00.00%) | 0.488 |
|  | Grade ≥ 3 | 0 (00.00%) | 0 (00.00%) | 0 (00.00%) | - |
Rash | Any | 1 (4.00%) | 2 (6.89%) | 1 (6.25%) | 0.895 |
|  | Grade ≥ 3 | 0 (00.00%) | 0 (00.00%) | 0 (00.00%) | - |
Gingival bleeding | Any | 2 (8.00%) | 2 (6.89%) | 1 (6.25%) | 0.975 |
|  | Grade ≥ 3 | 0 (00.00%) | 0 (00.00%) | 0 (00.00%) | - |
Insomnia | Any | 1 (4.00%) | 2 (6.89%) | 1 (6.25%) | 0.895 |
|  | Grade ≥ 3 | 0 (00.00%) | 0 (00.00%) | 0 (00.00%) | - |
Pneumonitis | Any | 0 (00.00%) | 1 (3.45%) | 1 (6.25%) | 0.488 |
|  | Grade ≥ 3 | 0 (00.00%) | 0 (00.00%) | 0 (00.00%) | - |