Table 3 Univariate analysis by prognostic factors for recurrence-free survival

Smoking

 Never

Ref

Ref

Ref

 Current or former

1.55 (1.03–2.34)

0.033

2.12 (1.15–3.89)

0.015

0.44 (0.15–1.22)

0.117

COPD

 No

Ref

Ref

Ref

 Yes

1.72 (0.98–3.01)

0.054

1.39 (0.43–0.46)

0.572

0.51 (0.11–2.23)

0.375

CEA

  < 3.8 ng/ml

Ref

Ref

Ref

  ≥ 3.8 ng/ml

2.57 (1.57–4.19)

 < 0.001

4.84 (2.23–10.46)

 < 0.001

1.75 (0.55–5.56)

0.339

pT

 pT1

Ref

Ref

Ref

 pT2a

2.02 (1.27–3.20)

0.003

1.91 (1.05–3.46)

0.031

2.44 (0.82–7.29)

0.108

 pT2b

3.73 (2.03–6.85)

 < 0.001

3.80 (1.62–8.97)

0.002

0.94 (0.11–7.92)

0.961

 pT3

3.81 (2.30–6.30)

 < 0.001

2.22 (0.95–5.19)

0.064

3.90 (1.09–13.94)

0.036

 pT4

4.98 (2.42–10.24)

 < 0.001

4.73 (1.41–15.83)

0.012

2.16 (0.25–18.29)

0.477

pN

 pN0

Ref

Ref

Ref

 pN1

3.88 (2.33–6.44)

 < 0.001

2.93 (1.48–5.78)

0.002

2.01 (0.40–10.07)

0.395

 pN2

4.31 (2.18–8.53)

 < 0.001

5.69 (3.08–10.51)

 < 0.001

7.43 (2.72–20.31)

 < 0.001

pStage

 I

Ref

Ref

Ref

 II

3.30 (2.12–5.13)

 < 0.001

2.15 (1.11–4.17)

0.022

7.16 (1.37–37.24)

0.019

 III

6.74 (4.40–10.33)

 < 0.001

6.53 (3.65–11.69)

 < 0.001

14.27 (3.18–64.02)

0.001

Margin

 Negative

Ref

Ref

Ref

 Positive

4.31 (2.18–8.53)

 < 0.001

3.81 (1.52–9.59)

0.004

1.44 (0.18–11.02)

0.724

LVI

 Negative

Ref

Ref

Ref

 Positive

3.28 (2.27–4.74)

 < 0.001

3.22 (1.90–5.43)

 < 0.001

5.96 (1.73–20.51)

0.005

Pleural invasion

 Negative

Ref

Ref

Ref

 Positive

2.35 (1.61–3.42)

 < 0.001

2.18 (1.28–3.71)

0.004

1.58 (0.59–4.18)

0.354

Histology

 Lepidic

Ref

Ref

Ref

 Acinar

2.59 (1.46–4.60)

0.001

3.54 (1.49–8.42)

0.004

0.91 (0.19–4.32)

0.908

 Micropapillary

5.41 (2.29–12.78)

 < 0.001

4.33 (0.87–21.54)

0.073

1.25 (0.23–6.72)

0.789

 Papillary

4.15 (2.02–8.50)

 < 0.001

4.58 (1.62–12.94)

0.004

1

 Solid

4.86 (2.27–10.40)

 < 0.001

10.66 (2.97–38.22)

 < 0.001

0.45 (0.072–2.85)

0.401

 Mucinous

2.83 (1.27–6.30)

 < 0.001

6.69 (1.33–33.49)

0.021

0.73 (0.06–8.10)

0.801

EGFR status

 Wild-type

Ref

-

-

 Mutated

0.88 (0.60–1.28)

0.518

-

-

PDL1 SP263

 Negative

Ref

-

-

  ≥ 1

1.75 (1.03–2.98)

0.036

-

-