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Table 4 Best overall response by Response Evaluation Criteria in Solid Tumors

From: High serum proteinase-3 levels predict poor progression-free survival and lower efficacy of bevacizumab in metastatic colorectal cancer

 

All specimens

With bevacizumab treatment

Without bevacizumab treatment

Serum PRTN3 low (n=34)

Serum PRTN3 high (n=45)

P-value

Serum PRTN3 low (n=10)

Serum PRTN3 high (n=19)

P-value

Serum PRTN3 low (n=24)

Serum PRTN3 high (n=26)

P-value

Best overall response

  

<0.001

  

<0.001

  

0.004

Partial response

21 (61.8)

5 (11.1)

 

8 (80.0)

2 (10.5)

 

13 (54.2)

3 (11.5)

 

Stable disease

10 (29.4)

27 (60.0)

 

2 (20.0)

13 (68.4)

 

8 (33.3)

14 (53.9)

 

Progressive disease

3 (8.8)

13 (28.9)

 

0

4 (21.1)

 

3 (12.5)

9 (34.6)

 
  1. Data are presented as n (%)
  2. Abbreviations: PRTN3 Proteinase-3