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Table 2 Univariate and multivariate analyses of risk factors of progression-free survival

From: High serum proteinase-3 levels predict poor progression-free survival and lower efficacy of bevacizumab in metastatic colorectal cancer

Factor

Cut-off

Univariate analysis

Multivariate analysis

HR

95% CI

P -value

HR

95% CI

P -value

Lower

Upper

Lower

Upper

Serum PRTN3 (ng/ml)

>21.6

2.173

1.269

3.723

0.005

2.082

1.188

3.647

0.010

Age (years)

>65

0.921

0.545

1.555

0.757

    

Sex

Male/female

1.162

1.162

1.940

0.565

    

WBC count (/µl)

>8600

1.707

0.922

3.162

0.089

1.807

0.964

3.388

0.065

Neutrophil count (/µl)

>4920

1.477

0.884

2.470

0.137

    

CEA level (ng/ml)

>6.0

0.893

0.354

2.254

0.812

    

CA19-9 level (U/ml)

>37

1.517

0.889

2.588

0.127

    

Tumor location

Right/left

1.263

0.756

2.109

0.372

    

T category

 

1.039

0.678

1.638

0.865

    

N category

 

1.360

1.050

1.756

0.020

1.222

0.931

1.604

0.148

Metastasis

a/b/c

1.200

0.808

1.725

0.355

    

Operation (radical resection)

R0, 1/R2, unresected

0.619

0.369

1.037

0.068

0.589

0.341

1.018

0.058

  1. Variables selected for the multivariate analysis were those with a univariate analysis p-value of < 0.10. 95% CI 95% confidence interval, CA19-9 Carbohydrate antigen19-9, CEA Carcinoembryonic antigen, WBC White blood cell