Fig. 5
From: Tretinoin improves the anti-cancer response to cyclophosphamide, in a model-selective manner
The expression of retinoic acid receptors and inflammatory genes in AB1-HA, AE17,CT26 and WEHI164 from bulk RNA sequencing data. Tumors from mice inoculated with AB1HA, AE17,CT26 or WEHI164 were harvested, and RNA was extracted and sequenced. (A–C) Expression of the three retinoic acid receptors. (D–F) Expression of the three retinoic X receptors. Counts were normalised to adjust for sequencing depth. (G) Heatmap of inflammatory genes. Counts were normalized and z scaled. (H) Inflammatory score of each tumor type, as calculated by taking the average expression of inflammation associated genes in each sample. (H) Immune score for each tumor as determined by ESTIMATE. Data are shown as mean ± SD and significance was determined using Mann-Whitney U tests corrected for multiple comparisons *p < 0.05, **p < 0.01 ***p < 0.001. n = 26 for AB1-HA, n = 8 for AE17, n = 10 for CT26 and n = 15 for WEHI164.