Fig. 2

Integrated analysis of single-cell GBM datasets shows the impact of PRNP expression. A Schematic workflow of single-cell RNA-seq (scRNA-seq) data analyses carried out on three independent and publicly available datasets. B UMAP representation of PRNP expression in GBM cells from Darmanis et al., Neftel et al., and Richards et al. (C) Venn diagram of common marker genes of PRNP⁺ cells in all scRNA-seq datasets. D Functional profiling (ORA, GO) of the 840 common genes found in (C), ranked by -log₁₀ (Adjusted p-value)