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Fig. 6 | BMC Cancer

Fig. 6

From: Hypoxia-induced miR-181a-5p up-regulation reduces epirubicin sensitivity in breast cancer cells through inhibiting EPDR1/TRPC1 to activate PI3K/AKT signaling pathway

Fig. 6

EPDR1/TRPC1 promotes epirubicin sensitivity in BC cells via inhibiting PI3K/AKT signaling pathway. (A) The proliferation of cells was examined by CCK-8 assay. (B) The migration and invasion of cells was examined by Transwell assay. (C) The expression of EMT-related protein was examined by western blot assay. 1, Vector group; 2, EPDR1 group; 3, EPDR1 + si-NC group; 4, EPDR1 + si-TRPC1 group; 5, EPDR1 + si-TRPC1 + DMSO group; 6, EPDR1 + si-TRPC1 + LY294002 group. *, vs. Vector group, p < 0.05; #, vs. EPDR1 group, p < 0.05; $, vs. EPDR1 + si-NC group, p < 0.05; &, vs. EPDR1 + si-TRPC1 group group, p < 0.05; @, vs. EPDR1 + si-TRPC1 + DMSO group, p < 0.05

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BMC Cancer

ISSN: 1471-2407

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