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Fig. 5 | BMC Cancer

Fig. 5

From: Hypoxia-induced miR-181a-5p up-regulation reduces epirubicin sensitivity in breast cancer cells through inhibiting EPDR1/TRPC1 to activate PI3K/AKT signaling pathway

Fig. 5

EPDR1 inhibits PI3K/AKT signaling pathway in BC epirubicin-resistant cells through upregulation of TRPC1. (A) Genes related to EPDR1 expression in breast cancer were analyzed through bioinformatics. (B) TRPC1 was positively correlated with EPDR1 expression. (C) GEPIA analysis showed that TRPC1 was lowly expressed in BC tissues. (D) Kaplan-Meier Plotter analysis. (E) The expression of TRPC1, PI3K and p-AKT were examined by western blot assay. *, vs. MCF7 group, p < 0.05. (F) The inhibition rates of epirubicin-treated MCF-7 and MCF-7/EPI cells were examined by CCK-8 assay. *, vs. MCF7 group, p < 0.05. (G) IC50 values; *, vs. MCF7 group, p < 0.05. (H) The expression of TRPC1, PI3K and p-AKT of MCF-7/EPI cells overexpressing EPDR1 or silencing TRPC1. *, vs. Vector group, p < 0.05; #, vs. EPDR1 group, p < 0.05; $, vs. EPDR1 + si-NC group, p < 0.05

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BMC Cancer

ISSN: 1471-2407

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