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Fig. 4 | BMC Cancer

Fig. 4

From: Hypoxia-induced miR-181a-5p up-regulation reduces epirubicin sensitivity in breast cancer cells through inhibiting EPDR1/TRPC1 to activate PI3K/AKT signaling pathway

Fig. 4

Hypoxia reduces epirubicin sensitivity in BC cells through miR-181a-5p/EPDR1. (A) MCF-7 cells in normoxic and hypoxic environments and treated with different concentrations of epirubicin to detect cell activity by CCK-8 assay. (B) The IC50 values. (C) CCK-8 assay. (D) The migration and invasion of cells were examined by Transwell assay. (E) The expression of EMT-related protein was examined by western blot assay. 1, Normoxia group; 2, hypoxia group; 3, hypoxia + inhibitor NC group; 4, hypoxia + miR-181a-5p inhibitor group; 5, hypoxia + miR-181a-5p inhibitor + si-NC group; 6, hypoxia + miR-181a-5p inhibitor + si-EPDR1 group. *, vs. Normoxia group, p < 0.05; #, vs. Hypoxia group, p < 0.05; $, vs. Hypoxia + inhibitor NC group, p < 0.05; &, vs. Hypoxia + miR-181a-5p inhibitor group, p < 0.05; @, vs. Hypoxia + miR-181a-5p inhibitor + si-NC group, p < 0.05

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BMC Cancer

ISSN: 1471-2407

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