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Fig. 1 | BMC Cancer

Fig. 1

From: Hypoxia-induced miR-181a-5p up-regulation reduces epirubicin sensitivity in breast cancer cells through inhibiting EPDR1/TRPC1 to activate PI3K/AKT signaling pathway

Fig. 1

EPDR1 lowly expressed in BC tissues, epirubicin-resistant BC cells and hypoxia-treated BC cells. (A) DEGs of GSE42568 dataset were analyzed by GEO2R. (B) DEGs of GSE54326 dataset were analyzed by GEO2R. (C) DEGs in the GSE111246 dataset were analyzed by GEO2R online analysis software. (D) The genes to be lowly expression in BC tissues, epirubicin-resistant BC cells and hypoxia-treated BC cells were analyzed by Venn diagram analysis. (E) The expression of EPDR1 mRNA in BC and paracancer tissues was examined by RT-qPCR; *, vs. Adjacent group, p < 0.05. (F) The expression of EPDR1 protein in BC and paracancer tissues was examined by Western blot; *, vs. Adjacent group, p < 0.05. (G) The expression of EPDR1 mRNA in epirubicin-resistant and parental MCF-7 cells was examined by RT-qPCR; *, vs. MCF7 group, p < 0.05. (H) The expression of EPDR1 protein in epirubicin-resistant and parental MCF-7 cells was examined by Western blot; *, vs. MCF7 group, p < 0.05. (I) The expression of EPDR1 mRNA in hypoxic and normoxic treated MCF-7 cells was examined by RT-qPCR; *, vs. Normoxia group, p < 0.05. (J) The expression of EPDR1 protein in hypoxic and normoxic treated MCF-7 cells was examined by western blot assay; *, vs. Normoxia group, p < 0.05

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BMC Cancer

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