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Table 2 Dose and fractionation in experimental arm (Single Fraction), with [secondary options in square brackets]

From: Single vs. multiple fraction non-inferiority trial of stereotactic ablative radiotherapy for the comprehensive treatment of oligo-metastases/progression: SIMPLIFY-SABR-COMET

Location

Dose (Gy)

Fractions

Tumour BED (Gy10)

Lung

Greater than 2 cm from mediastinum or brachial plexus or if mandatory OAR constraints are met

30 [34]

1

120 [149.6]

Within 2 cm of mediastinum or brachial plexus

20

1

60

Bone

Any bone

20

1

60

Liver

30 [34]

1

120 [149.6]

Spine

20

1

60

Adrenal

20

1

60

Lymph node/ soft tissue

20

1

60

Brain

Dose per institutional policy

1

Â