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Table 1 Dose and fractionations in standard of care arm (multi-fraction) by site with [secondary options in square brackets]

From: Single vs. multiple fraction non-inferiority trial of stereotactic ablative radiotherapy for the comprehensive treatment of oligo-metastases/progression: SIMPLIFY-SABR-COMET

Location

Dose (Gy)

Fractions

Dose per fraction (Gy)

Tumour BED (Gy10)

Frequency

Lung

Greater than 2 cm from mediastinum or brachial plexus or if mandatory OAR constraints are met

48 [54]

4 [3]

12 [18]

105.6 [151.2]

Daily or every second day

Within 2 cm of mediastinum or brachial plexus

60 [50]

8 [5]

7.5 [10]

105 [100]

Daily

Bone

Any bone except spine

35

5

7

59.5

Daily

Liver

54 [50]

3 [5]

18 [10]

151.2 [112.3]

Daily or every second day

Spine

24 [35]

2 [5]

12 [7]

52.8 [59.5]

Daily

Adrenal

40 [35]

5

8 [7]

72 [59.5]

Daily

Lymph node/soft tissue

40 [35]

5

8 [7]

72 [59.5]

Daily

Brain

Dose per institutional policy

   Â