Fig. 3

Relative risks (RRs) of discontinuation due to TRAEs across various solid tumors

(A) Forest plot of RR of treatment discontinuation due to TRAEs. (B) Direct and overall comparisons of discontinuation due to TRAEs. Each cell contains pooled RR with 95% CI. An RR greater than 1 means that upper-row treatment has a greater risk of treatment discontinuation. The overall comparison outcomes, which combine direct and indirect comparison results from the network meta-analysis are displayed in the left lowerhalf, while results from pairwise meta-analysis are shown in the right upper half, if available. Significant results are in bold. Chemo-dual-IO indicates dual-immunotherapy combined with chemotherapy; Chemo-IO, mono-immunotherapy combined with chemotherapy; Chemo-only, chemotherapy alone; CI, confidence interval; dual-IO, dual-immunotherapy; mono-IO, mono-immunotherapy; NA, not available; RR, relative risk; TRAE, treatment-related adverse event.