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Fig. 8 | BMC Cancer

Fig. 8

From: FBXO28 promotes cell proliferation, migration and invasion via upregulation of the TGF-beta1/SMAD2/3 signaling pathway in ovarian cancer

Fig. 8

FBXO28 knockdown inhibits tumor growth in vivo. A. Images of xenograft tumors obtained 34 days after injection of SKOV3-knockdown cells or corresponding control cells in nude mice. B. Changes in tumor volume measured at 4-day intervals after injection of SKOV3-knockdown cells or corresponding control cells in nude mice. Tumor volume = (L×W2)/2. CC. Images of the collected graft tumors. D. The weight of each xenograft tumor. E. Representative images of subcutaneous tumor samples from the SKOV3 knockdown and corresponding control groups subjected to immunohistochemical staining for the FBXO28, N-cadherin, E-cadherin and Ki67 proteins. **P < 0.01. F: Left panel: Relationship between FBXO28 expression and PFS in ovarian cancer patients. Right panel: correlation between FBXO28 expression and OS in ovarian cancer patients. **P < 0.01.

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BMC Cancer

ISSN: 1471-2407

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