Table 3 Overall Response Rate and Related Factors

Best tumor response (n, %)

Complete response

42 (12.2)

-

-

-

-

Partial response

226 (65.9)

Stable disease

50 (14.6)

Progressive disease

25 (7.3)

Age

•       < 65 years old

117 (77.0)

0.643

1.00 (reference)

-

-

•       ≥ 65 years old

151 (79.1)

0.89 (0.53–1.48)

Gender

•       Male

153 (78.9)

0.596

1.00 (reference)

-

-

•       Female

116 (77.8)

0.91 (0.54–1.52)

ECOG

•       PS 0–1

253 (79.3)

0.055

1.00 (reference)

0.049

1.00 (reference)

•       PS 2–3

15 (62.5)

0.44 (0.18–1.04)

0.41 (0.17–0.99)

Smoking status

•       Current smoker

73 (77.7)

0.896

1.00 (reference)

-

-

•       Non/former smoker

195 (78.3)

1.04 (0.59–1.84)

EGFR mutations

•       Del 19

133 (82.6)

0.082^a

1.00 (reference)

-

-

•       L858R

66 (73.3)

0.58 (0.31–1.08)

•       Del 19 + L858R

199 (79.3)

0.419^b

-

•       Uncommon mutations

69 (75.0)

0.63 (0.34–1.18)

Stage

•       IV

23 (74.2)

0.578

1.00 (reference)

-

-

•       IIIB, IIIC, recurrence

245 (78.5)

0.79 (0.34–1.84)

Brain metastasis

•       Yes

62 (71.3)

0.073

1.00 (reference)

-

-

•       No

206 (80.5)

1.66 (0.95–2.90)

Starting dose

•       40 mg

115 (83.9)

0.034

1.00 (reference)

0.029

1.00 (reference)

•       < 40 mg

153 (74.3)

0.55 (0.32–0.96)

0.54 (0.31–0.94)