Table 2 Afatinib dosage and treatment features

Starting dose

 • 20 mg

5 (1.5)

 • 30 mg

201 (58.6)

 • 40 mg

137 (39.9)

Dose adjustment after 1 month

 • Dose increase

25 (7.3)

 • Dose reduction

37 (10.8)

 • Dose maintain

281 (81.9)

Dose reductions during treatment

 • Yes

81 (23.6)

 • No

262 (76.4)

Optimal dose

 • 20 mg

16 (4.7)

 • 30 mg

213 (62.1)

 • 40 mg

114 (33.2)

Treatment in the local of brain metastases (at the time of initiation of treatment)

 • Whole Brain Radiation

24 (27.6)

 • Gamma Knife

14 (16.1)

Other palliative treatment

 • Radiation relieves bone pain

10 (2.9)

 • Radiation therapy to the chest

1 (0.3)

 • Other

9 (2.6)