Fig. 4

Weighted gene co-expression network analysis (WGCNA) of metabolic subtype characteristic index-related genes in the three ESCA subtypes in the TCGA cohort. Analysis of network topology for various soft thresholding powers (A-C). D Hierarchical cluster tree displaying 12 modules of co-expressed genes. E The distribution of eigenvectors of 13 modules in the 3 metabolic subtypes. F Heatmap showing the correlations of each module with Age, Gender, T Stage, N Stage, M Stage, MC1, MC2 and MC3 subtypes. G Scatter diagram for module membership vs. gene significance for MC2 in the green module. H Scatter diagram for module membership vs. gene significance for MC2 in the yellow module. I Scatter diagram for module membership vs. gene significance for MC3 in the turquoise module