Fig. 1

Identification of metabolic subtypes in the ESCA sample from the TCGA and GEO cohorts. A The cumulative distribution function (CDF) curves of consensus scores based on different subtype number (k = 2 ~ 6) in the TCGA-ESCA cohort. B The CDF Delta area curve of all samples in the TCGA-ESCA cohort when k = 3. C The consensus score matrix of ESCA samples in the TCGA-ESCA cohort when k = 3 (1 = MC1, 2 = MC2, 3 = MC3). D and E Kaplan–Meier curves showing the distinct OS (D) and PFS (E) of patients in the three metabolic-related subtypes in the TCGA-ESCA cohort. F The cumulative distribution function (CDF) curves of consensus scores based on different subtype number (k = 2 ~ 6) in the GEO-ESCA cohort. G The CDF Delta area curve of all samples in the GEO-ESCA cohort when k = 3. H The consensus score matrix of samples in the GEO-ESCA cohort when k = 3 (1 = MC1, 2 = MC2, 3 = MC3). I Kaplan–Meier curves showing the distinct OS of patients in the three metabolic-related subtypes in the GEO-ESCA cohort