Table 2 Univariate and multivariate Cox regression analysis of prognosis for OS in nCRT patients

Age, years

0.97(0.95-1)

0.169

Sex

1.55(0.84–2.87)

0.158

Differentiation

 Gx

1

1

 G1

1.27(0.37–4.32)

0.703

0.39(0.06–2.54)

0.323

 G2

2.29(1.25–4.19)

0.007

0.56(0.12–2.70)

0.472

 G3

3.60(2.05–6.32)

0

0.78(0.16–3.78)

0.759

ypT

 0

1

1

 1

1.59(0.65–3.87)

0.306

1.18(0.24–5.71)

0.840

 2

1.86(0.86–3.99)

0.116

1.24(0.20–7.53)

0.816

 3

3.83(2.18–6.73)

0

1.85(0.31–11.04)

0.498

ypN

 0

1

1

 1

3.34(2.02–5.52)

0

2.97(1.73–5.09)

0

 2

3.50(1.85–6.60)

0

2.85(1.39–5.82)

0.004

 3

18.38(8.13–41.60)

0

10.68(4.32–26.39)

0

Pathological Stage

 0

1

 1

2.51(25.58 − 0.4)

0.013

 2

4.7(25.58 − 0.4)

0

 3

25.58(25.58 − 0.4)

0

Tumor location

 Proximal third

1

 Middle third

1.05(0.51–2.15)

0.897

 Distal third

1.11(0.53–2.34)

0.785

Tumor length, cm

1.26(1.16–1.37)

0

1.13(0.98–1.31)

0. 099

ELN

0.99(0.97–1.02)

0.428

0.84

E-LNS

0.93(0.871)

0.038

0.90(0.84–0.97)

0.007

TRG

 0

1

 1

1.53(0.63–3.71)

0.352

 2

3.13(1.76–5.55)

 3

3.57(1.78–7.14)

Smoke

1.67(1.06–2.63)

0.028

1.43(0.90–2.28)

0.127

Comorbidity

1.06(0.66–1.68)

0.82