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Table 2 1-, 3-, and 5-year survival rate of H-CHOP and R-CHOP for the overall population, those who had completed 6 cycles of treatment, IPI 1, and IPI 2

From: Long-term outcomes with HLX01 (HanliKang®), a rituximab biosimilar, in previously untreated patients with diffuse large B-cell lymphoma: 5-year follow-up results of the phase 3 HLX01-NHL03 study

 

Survival rate (95% CI)

OS

PFS

H-CHOP

R-CHOP

H-CHOP

R-CHOP

Overall

population

1-year

93.6 (89.9–97.5)

94.3 (90.8–98.0)

92.3 (88.3–96.6)

91.8 (87.7–96.2)

3-year

87.8 (82.8–93.1)

85.5 (80.2–91.2)

83.2 (77.6–89.3)

82.4 (76.7–88.5)

5-year

81.0 (74.9–87.5)

75.4 (68.9–82.6)

77.7 (71.4–84.6)

73.0 (66.3–80.3)

Patients who had completed 6 cycles of treatment

1-year

95.6 (92.3–99.1)

95.9 (92.7–99.2)

94.1 (90.3–98.2)

93.8 (90.0-97.8)

3-year

90.4 (85.6–95.5)

86.3 (80.9–92.1)

85.2 (79.4–91.4)

83.6 (77.8–89.8)

5-year

83.3 (77.2–90.0)

77.6 (71.0-84.8)

79.6 (73.0-86.8)

75.6 (68.9–83.0)

IPI 1

1-year

95.7 (91.1–100)

95.2 (90.7–99.9)

94.3 (89.0-99.9)

95.2 (90.7–99.9)

3-year

89.9 (83.1–97.3)

89.2 (82.7–96.1)

84.1 (76.0-93.2)

85.5 (78.3–93.5)

5-year

86.8 (79.0-95.2)

80.2 (71.9–89.4)

84.1 (76.0-93.2)

75.3 (66.4–85.3)

IPI 2

1-year

91.5 (95.6–97.7)

92.9 (87.0-99.1)

90.2 (84.0-96.9)

87.1 (79.6–95.3)

3-year

86.5 (79.4–94.3)

80.0 (71.2–89.9)

82.7 (74.8–91.4)

87.1 (67.9–87.6)

5-year

76.2 (67.4–86.2)

68.0 (57.7–80.0)

72.0 (62.6–82.7)

68.2 (58.0-80.1)