Fig. 6

Kaplan–Meier survival curves of CTLA-4, PD-1, PD-L1, B7-H3, B7-H4, IDO1, EphA2, CD68, and Ki-67 in lung adenocarcinoma brain metastases patients. (A-D) CTLA-4 (P = 0.441), PD-1 (P = 0.162), PD-L1 (P = 0.347), and B7-H3 (P = 0.630) expression was not correlated with patient survival. (E and F) High expression of B7-H4 and IDO1 in tumor cells was associated with worse survival (P = 0.004 and P = 0.011, respectively). (G) EphA2 expression in tumor cells was not associated with patient survival (P = 0.482). (H) High CD68⁺ cells in the stroma were associated with worse survival (P = 0.024). (I) Ki-67 index was not associated with patient survival (P = 0.116). The significance in survival differences was analyzed by log-rank test