Fig. 4From: Spatial and temporal heterogeneity of tumor immune microenvironment between primary tumor and brain metastases in NSCLCInfiltration differences of TILs in synchronous and metachronous brain metastases patients. The infiltration of CD8+ lymphocytes were remarkably decreased in synchronously metastatic brain lesions (P = 0.034). No significant difference was observed between the paired lesions of synchronous and metachronous metastases among the other markers. *, P < 0.05; ns, not significant. The significance in difference was analyzed by Mann-Whitney U TestBack to article page