Table 3 Univariate and multivariate analyses of clinicopathological factors associated with disease-free survival after hepatectomy
From: Role of stromal PD-L1 expression in colorectal liver metastasis
Variables | 5-year DFS rate (%) | Uni-variate P-value | Multivariate analysis | |
|---|---|---|---|---|
HR (95% CI) | P-value | |||
< Metastatic tumor characteristics > | Â | Â | Â | Â |
Age (< 70 years / ≥70 years) | 27.3 / 35.3 | 0.83 |  |  |
Sex (men/women) | 34.3 / 27.1 | 0.86 | Â | Â |
Tumor maximum size (< 5 cm / ≥5 cm) | 33.5 / 26.6 | 0.41 |  |  |
Tumor number (< 5 / ≥5) | 33.9 / 32.0 | 0.31 |  |  |
H-stage (H1/H2, 3) | 36.8 / 21.4 | 0.08 | Â | Â |
Grade (A/B,C) | 41.1 / 18.4 | 0.007 | 0.57 (0.32–1.01) | 0.05 |
Metastasis period (synch/meta) | 41.7 / 23.0 | 0.02 | 0.69 (0.38–1.23) | 0.21 |
Pre-operative chemotherapy (- : +) | 31.8 / 30.7 | 0.64 | Â | Â |
Post-operative chemotherapy (- : +) | 39.2 / 28.7 | 0.44 | Â | Â |
Stromal PD-L1 (- : +) | 20.5 / 41.0 | 0.03 | 0.71 (0.38–1.32) | 0.28 |
Tumor PD-L1 (- : +) | 26.6 / 35.8 | 0.39 | Â | Â |
PD-1 (- : +) | 25.5 / 52.8 | 0.08 | Â | Â |
TILs (low : high) | 30.6 / 37.5 | 0.69 | Â | Â |
Replacement subtype (- : +) | 34.8 / 25.2 | 0.42 | Â | Â |
Desmoplastic subtype (- : +) | 21.5 / 45.6 | 0.04 | 0.75 (0.39–1.44) | 0.39 |
Pushing subtype (- : +) | 36.5 / 15.9 | 0.22 | Â | Â |
< Primary tumor characteristics > | Â | Â | Â | Â |
Colon / rectum | 37.9 / 24.2 | 0.40 | Â | Â |
Tumor differentiation (diff./undiff.) | 30.6 / 00.0 | < 0.0001 | 0.11 (0.03–0.41) | 0.001 |
T (2,3/4) | 31.8 / 23.4 | 0.46 | Â | Â |
Lymph node metastasis (- : +) | 42.0 / 22.5 | 0.09 | Â | Â |
Lymphatic invasion (- : +) | 24.1 / 35.8 | 0.34 | Â | Â |
Venous invasion (- : +) | 31.8 / 23.4 | 0.56 | Â | Â |