Table 2 Univariate and multivariate analyses of clinicopathological factors associated with overall survival after hepatectomy
From: Role of stromal PD-L1 expression in colorectal liver metastasis
Variable | 5-year OS rate (%) | Uni-variate P-value | Multivariate analysis | |
|---|---|---|---|---|
HR (95% CI) | P-value | |||
< Metastatic tumor characteristics > | Â | Â | Â | Â |
Age (< 70 years / ≥70 years) | 74.3 / 59.1 | 0.31 |  |  |
Sex (men/women) | 64.3 / 70.6 | 0.72 | Â | Â |
Tumor maximum size (< 5 cm / ≥5 cm) | 67.5 / 60.7 | 0.08 |  |  |
Tumor number (< 5 / ≥5) | 70.1 / 51.8 | 0.35 |  |  |
H-stage (H1/H2, 3) | 74.3 / 48.4 | 0.03 | 0.81 (0.28–2.30) | 0.69 |
Grade (A/B,C) | 81.4 / 48.1 | 0.002 | 0.43 (0.15–1.22) | 0.11 |
Metastasis period (synch/meta) | 80.3 / 52.7 | 0.06 | Â | Â |
Pre-operative chemotherapy (- : +) | 65.5 / 6757 | 0.51 | Â | Â |
Post-operative chemotherapy (- : +) | 61.9 / 67.7 | 0.52 | Â | Â |
Stromal PD-L1 (- : +) | 48.8 / 78.8 | 0.003 | 0.33 (0.15–0.75) | 0.008 |
Tumor PD-L1 (- : +) | 51.1 / 87.5 | 0.004 | 0.65 (0.30–1.40) | 0.27 |
PD-1 (- : +) | 60.2 / 83.8 | 0.05 | Â | Â |
TILs (low : high) | 62.6 / 81.3 | 0.15 | Â | Â |
Replacement subtype (- : +) | 68.5 / 60.4 | 0.71 | Â | Â |
Desmoplastic subtype (- : +) | 55.8 / 75.8 | 0.05 | Â | Â |
Pushing subtype (- : +) | 70.9 / 47.0 | 0.05 | Â | Â |
< Primary tumor characteristics > | Â | Â | Â | Â |
Colon / rectum | 65.4 / 66.4 | 0.63 | Â | Â |
Tumor differentiation (diff./undiff.) | 67.9 / 00.0 | < 0.001 | 0.02 (0.001–0.32) | 0.001 |
T (2,3/4) | 74.0 / 35.2 | 0.04 | 0.57 (0.25–1.32) | 0.19 |
Lymph node metastasis (- : +) | 74.1 / 58.8 | 0.14 | Â | Â |
Lymphatic invasion (- : +) | 74.1 / 61.5 | 0.69 | Â | Â |
Venous invasion (- : +) | 77.7 / 58.3 | 0.24 | Â | Â |