Table 1 Clinicopathological characteristics in accordance with stromal PD-L1 expression
From: Role of stromal PD-L1 expression in colorectal liver metastasis
Variables | Stromal PD-L1(-) (n = 40) | Stromal PD-L1(+) (n = 44) | p-value |
|---|---|---|---|
< Metastatic tumor characteristics > | Â | Â | Â |
Age (years) | 66.6 ± 12.2 | 65.1 ± 10.4 | 0.54 |
Sex (men / women) | 30/10 | 27/17 | 0.17 |
Tumor maximum size (cm) | 3.5 ± 2.2 | 3.6 ± 2.0 | 0.67 |
Tumor number (< 5 / ≥5) | 25/15 | 32/12 | 0.33 |
H-stage (H1 / H2, 3) | 23/17 | 31/13 | 0.21 |
Grade (A / B,C) | 17/23 | 27/17 | 0.08 |
Metastasis period (synch / meta) | 14/26 | 24/20 | 0.07 |
Pre-operative chemotherapy (- / +) | 36/4 | 37/7 | 0.42 |
Post-operative chemotherapy (- / +) | 10/30 | 15/29 | 0.36 |
Not optimally resectable (- / +) | 9/31 | 19/25 | 0.04 |
Tumor PD-L1 expression (- / +) | 21/19 | 14/30 | 0.05 |
PD-1 expression (- / +) | 31/9 | 33/11 | 0.79 |
HGP (replacement / desmoplastic / pushing) | 20/8/12 | 10/26/8 | 0.0009 |
Replacement subtype (- : +) | 20/20 | 34/10 | 0.008 |
Desmoplastic subtype (- : +) | 32/8 | 18/26 | 0.0002 |
Pushing subtype (- : +) | 28/12 | 36/8 | 0.20 |
TILs (low : high) | 35/5 | 33/11 | 0.14 |
< Primary tumor characteristics > | Â | Â | Â |
Tumor differentiation (diff./undiff.) | 38/2 | 43/1 | 0.67 |
T (2,3/4)* | 34/9 | 30/8 | 0.99 |
Location (colon/rectum) | 25/15 | 20/24 | 0.12 |
Lymph node metastasis (-/+) | 18/22 | 20/24 | 0.97 |
Venous invasion (-/+)* | 15/22 | 15/26 | 0.72 |
Lymphatic invasion (-/+)* | 12/25 | 16/25 | 0.54 |