Table 3 Univariate and multivariate analyses of clinical factors associated with OS
Variables | Univariable Analysis | Multivariable Analysis | |||||
|---|---|---|---|---|---|---|---|
HR (95% CI) | Waldχ2 | P | HR (95% CI) | Waldχ2 | P | ||
Sex | |||||||
Female vs. female | 0.674(0.459 ~ 0.991) | 4.031 | 0.045 | 0.691(0.463 ~ 1.030) | 3.294 | 0.070 | |
Age | |||||||
≥ 60 vs. <60 | 1.147(0.781 ~ 1.683) | 0.487 | 0.485 | - | - | - | |
KPS | |||||||
≥ 80 vs. <80 | 0.852(0.579 ~ 1.256) | 0.652 | 0.419 | - | - | - | |
Symptomatic BM | |||||||
YES vs. NO | 0.837(0.55 ~ 1.275) | 0.687 | 0.407 | - | - | - | |
Initial BM | |||||||
YES vs. NO | 1.023(0.687 ~ 1.523) | 0.013 | 0.911 | - | - | - | |
RT pattern | 5.083 | 0.079 | 3.508 | 0.173 | |||
WBRT | 1.000 | 1.000 | - | - | |||
LCRT | 0.672(0.424 ~ 1.064) | 2.875 | 0.090 | 1.020(0.569 ~ 1.827) | 0.004 | 0.947 | |
WBRT + LCRT | 0.616(0.384 ~ 0.988) | 4.047 | 0.044 | 0.655(0.399 ~ 1.074) | 2.818 | 0.093 | |
Lung-molGPA | |||||||
3–4 vs. 1-2.5 | 0.847(0.579 ~ 1.240) | 0.726 | 0.394 | - | - | - | |
Gene-mutation type | |||||||
ALK vs. EGFR | 0.646(0.283 ~ 1.475) | 1.076 | 0.300 | - | - | - | |
Generation of TKI | |||||||
Second and third vs. First | 0.547(0.363 ~ 0.825) | 8.296 | 0.004 | 0.423(0.268 ~ 0.666) | 13.796 | < 0.001 | |
Metastases | |||||||
Poly vs. oligometastases | 2.247(1.500 ~ 3.365) | 15.427 | < 0.001 | 2.052(1.115 ~ 3.777) | 5.335 | 0.021 | |
Extracranial disease | |||||||
YES vs. NO | 1.632(1.115 ~ 2.388) | 6.360 | 0.012 | 1.135(0.701 ~ 1.836) | 0.265 | 0.607 | |
BM diameter | |||||||
≥ 2 cm vs. <2 cm | 0.805(0.548 ~ 1.183) | 1.222 | 0.269 | - | - | - | |
BM number | |||||||
> 3 vs. ≤3 | 1.621(1.100 ~ 2.389) | 5.952 | 0.015 | 0.974(0.545 ~ 1.741) | 0.008 | 0.928 | |
Treatment regimen | |||||||
deferred RT vs. upfront RT | 1.518(1.036 ~ 2.224) | 4.591 | 0.032 | 1.531(1.011 ~ 2.318) | 4.055 | 0.044 | |