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Table 2 Univariate and multivariate analyses of clinical factors associated with iPFS.

From: Analysis of the efficacy of upfront brain radiotherapy versus deferred radiotherapy for EGFR/ALK-positive non-small cell lung cancer with brain metastases: a retrospective study

Variables

Univariable Analysis

 

Multivariable Analysis

HR (95% CI)

Waldχ2

P

HR (95% CI)

Waldχ2

P

Sex

       

Female vs. female

0.854(0.547 ~ 1.333)

0.485

0.486

 

-

-

-

Age

       

≥ 60 vs. <60

1.246(0.810 ~ 1.917)

1.004

0.316

 

-

-

-

KPS

       

≥ 80 vs. <80

0.740(0.476 ~ 1.150)

1.791

0.181

 

-

-

-

Symptomatic BM

       

YES vs. NO

1.073(0.654 ~ 1.763)

0.078

0.779

 

-

-

-

Initial BM

       

YES vs. NO

0.846(0.546 ~ 1.312)

0.558

0.455

 

-

-

-

RT pattern

 

2.449

0.294

    

WBRT

1.000

   

-

-

-

LCRT

1.163(0.706 ~ 1.917)

0.353

0.552

 

-

-

-

WBRT + LCRT

0.753(0.433 ~ 1.31)

1.007

0.316

 

-

-

-

Lung-molGPA

       

3–4 vs. 1-2.5

0.685(0.444 ~ 1.056)

2.931

0.087

 

0.819(0.486 ~ 1.380)

0.562

0.454

Gene-mutation type

       

ALK vs. EGFR

1.292(0.644 ~ 2.593)

0.521

0.471

 

-

-

-

Generation of TKI

       

Second and third vs. First

0.768(0.468 ~ 1.260)

1.089

0.297

    

Metastases

       

Poly vs. Oligometastases

1.322(0.859 ~ 2.035)

1.610

0.204

    

Extracranial disease

       

YES vs. NO

1.557(1.010 ~ 2.400)

4.028

0.045

 

1.304(0.769 ~ 2.210)

0.972

0.324

BM diameter

       

≥ 2 cm vs. <2 cm

0.861(0.561 ~ 1.322)

0.467

0.495

 

-

-

-

BM number

       

> 3 vs. ≤3

1.059(0.690 ~ 1.624)

0.069

0.793

 

-

-

-

Treatment regimen

       

deferred RT vs. upfront RT

1.651(1.076 ~ 2.532)

5.277

0.022

 

1.571(1.020 ~ 2.418)

4.210

0.040

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BMC Cancer

ISSN: 1471-2407

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